Clinical Experiences – Examples

(From published articles in clinical journals)

Highly Specific for anti-A/B antibodies:

Minimal influence on other plasma components and minimum of other complications.

Thus, more patient plasma volumes can be treated per session and if necessary more sessions can be performed

Also patients with high titers can be treated to low titers, 1:4 or lower

Specific treatment:

Minimal bleeding, infections and other complications

Lower dose of, or no IVIG required (IVIG contains anti-A/B antibodies)

No substituents, e.g. AB plasma (soluble A/B antigens, other side reactions)

ABO-incompatible LD Kidney Transplants:

Low titer 1:4 or lower, pre-transplant – low frequency of rejection reactions

For example, Stockholm, Freiburg: Adults, excellent results – similar to ABO-compatible LD

Stockholm: Pediatric, also small children, excellent results

Liver, Heart, Lung, Kidney/Pancreas:

Lowering of anti-A/B titer and decrease the risk for rejection

Stem cell transplants: Alternative to hemolysis, multiple transfusions, PE, GVHD

Sterile, clean product, No chemicals added^*, Similar infection risk as for ABO-compatible transplants

^*Other products may contain e.g. Sodium azide¹, a highly toxic and mutagenic substance

¹Sodium azide is also used as en explosive

Sodium azide does not protect against for example streptococci and pneumococci